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Target
Tubulin beta-2B chain
Ligand
BDBM50060956
Substrate
n/a
Meas. Tech.
ChEMBL_211335 (CHEMBL820778)
IC50
2800±n/a nM
Citation
 Miller, TA; Bulman, AL; Thompson, CD; Garst, ME; Macdonald, TL Synthesis and structure-activity profiles of A-homoestranes, the estratropones. J Med Chem 40:3836-41 (1997) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50060956
Synonyms:
(1S,3aS,3bR,10bS,12aS)-8-Chloro-1-hydroxy-12a-methyl-2,3,3a,3b,4,5,10b,11,12,12a-decahydro-1H-cyclohepta[a]cyclopenta[f]naphthalen-7-one | CHEMBL339413
Type:
Small organic molecule
Emp. Form.:
C19H23ClO2
Mol. Mass.:
318.838
SMILES:
C[C@]12CC[C@H]3[C@@H](CCc4cc(=O)c(Cl)ccc34)[C@@H]1CC[C@@H]2O
Structure:
Search PDB for entries with ligand similarity: