Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50510072
Substrate
n/a
Meas. Tech.
ChEMBL_1840051 (CHEMBL4340266)
Ki
2.5±n/a nM
Citation
 Gao, M; Wang, M; Meyer, JA; Territo, PR; Hutchins, GD; Zarrinmayeh, H; Zheng, QH Synthesis and in vitro biological evaluation of new P2X7R radioligands [ Bioorg Med Chem Lett 29:1476-1480 (2019) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50510072
Synonyms:
CHEMBL4435339
Type:
Small organic molecule
Emp. Form.:
C14H14BrF3N2O2
Mol. Mass.:
379.172
SMILES:
CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Br)C(F)(F)F |r|
Structure:
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