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Target
Platelet-activating factor receptor
Ligand
BDBM50408421
Substrate
n/a
Meas. Tech.
ChEMBL_158343 (CHEMBL768487)
IC50
2±n/a nM
Citation
 Cai, X; Scannell, RT; Yaeger, D; Hussoin, MS; Killian, DB; Qian, C; Eckman, J; Hwang, SB; Libertine-Garahan, L; Yeh, CG; Ip, SH; Shen, TY (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist. J Med Chem 41:1970-9 (1998) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50408421
Synonyms:
CHEMBL2113725
Type:
Small organic molecule
Emp. Form.:
C33H38F4N2O8S
Mol. Mass.:
698.722
SMILES:
CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Structure:
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