Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50510592
Substrate
n/a
Meas. Tech.
ChEMBL_1841760 (CHEMBL4342059)
IC50
58130±n/a nM
Citation
 Jamal Gilani, S; Zaheen Hassan, M; Sarim Imam, S; Kala, C; Prakash Dixit, S Novel benzothiazole hydrazine carboxamide hybrid scaffolds as potential in vitro GABA AT enzyme inhibitors: Synthesis, molecular docking and antiepileptic evaluation. Bioorg Med Chem Lett 29:1825-1830 (2019) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 2.6.1.19 | 2.6.1.22 | 4-aminobutyrate aminotransferase, mitochondrial | Abat | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABT_MOUSE | Gabat | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
PROTEIN
Mol. Mass.:
56462.31
Organism:
Mus musculus
Description:
ChEMBL_119008
Residue:
500
Sequence:
MAFLLITRRLACSSQKNLHLFIPGSRYISQAAAKVDIEFDYDGPLMKTEVPGPRSKELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLQESLMSVAPRGMSQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFTTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVARVGKTLLTGLLDLQAQYPQFISRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLSIFSGILADFK
  
Inhibitor
Name:
BDBM50510592
Synonyms:
CHEMBL4452708
Type:
Small organic molecule
Emp. Form.:
C17H12ClN5O4S2
Mol. Mass.:
449.891
SMILES:
[O-][N+](=O)c1ccc(cc1)C1SCC(=O)N1NC(=O)Nc1nc2ccc(Cl)cc2s1
Structure:
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