Reaction Details Report a problem with these data
Target
Platelet-derived growth factor receptor alpha
Ligand
BDBM50510912
Substrate
n/a
Meas. Tech.
ChEMBL_1842659 (CHEMBL4343086)
IC50
94±n/a nM
Citation
 ?ezní?ková, E; Gucký, T; Ková?ová, V; Ajani, H; Jorda, R; Kry?tof, V Activity of 2,6,9-trisubstituted purines as potent PDGFR? kinase inhibitors with antileukaemic activity. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor receptor alpha
Synonyms:
Alpha-type platelet-derived growth factor receptor | PDGFR2 | PDGFRA | PDGFRalpha | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFR-alpha) | Platelet-derived growth factor receptor alpha (PDGFRA) | Platelet-derived growth factor receptor, alpha polypeptid | RHEPDGFRA
Type:
Protein
Mol. Mass.:
122633.38
Organism:
Homo sapiens (Human)
Description:
P16234
Residue:
1089
Sequence:
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
  
Inhibitor
Name:
BDBM50510912
Synonyms:
CHEMBL4564698
Type:
Small organic molecule
Emp. Form.:
C25H36N8O2
Mol. Mass.:
480.6057
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(CCCO)c2n1 |r,wU:1.0,wD:4.7,(55.15,-40.57,;56.48,-41.34,;57.81,-40.58,;59.14,-41.35,;59.13,-42.89,;57.8,-43.67,;56.47,-42.89,;60.47,-43.67,;61.8,-42.89,;61.8,-41.35,;63.13,-40.58,;63.13,-39.04,;64.46,-38.26,;65.8,-39.04,;67.12,-38.26,;67.12,-36.72,;68.45,-35.95,;69.79,-36.71,;69.78,-38.25,;71.12,-39.01,;72.45,-38.24,;72.45,-36.7,;71.11,-35.93,;65.78,-35.96,;64.45,-36.73,;64.47,-41.34,;65.94,-40.87,;66.84,-42.12,;65.94,-43.37,;65.93,-44.9,;67.25,-45.68,;68.59,-44.93,;69.92,-45.71,;64.47,-42.89,;63.14,-43.67,)|
Structure:
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