Reaction Details Report a problem with these data
Target
Platelet-derived growth factor receptor alpha
Ligand
BDBM50510921
Substrate
n/a
Meas. Tech.
ChEMBL_1842659 (CHEMBL4343086)
IC50
182±n/a nM
Citation
 ?ezní?ková, E; Gucký, T; Ková?ová, V; Ajani, H; Jorda, R; Kry?tof, V Activity of 2,6,9-trisubstituted purines as potent PDGFR? kinase inhibitors with antileukaemic activity. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor receptor alpha
Synonyms:
Alpha-type platelet-derived growth factor receptor | PDGFR2 | PDGFRA | PDGFRalpha | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFR-alpha) | Platelet-derived growth factor receptor alpha (PDGFRA) | Platelet-derived growth factor receptor, alpha polypeptid | RHEPDGFRA
Type:
Protein
Mol. Mass.:
122633.38
Organism:
Homo sapiens (Human)
Description:
P16234
Residue:
1089
Sequence:
MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL
  
Inhibitor
Name:
BDBM50510921
Synonyms:
CHEMBL4564044
Type:
Small organic molecule
Emp. Form.:
C27H31BrN8O
Mol. Mass.:
563.492
SMILES:
N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2ccc(Oc3ccc(Br)cn3)cc2)c2ncn(C3CCCC3)c2n1 |r,wU:1.0,wD:4.7,(53.25,-7.95,;54.58,-8.72,;55.92,-7.96,;57.24,-8.73,;57.23,-10.27,;55.91,-11.04,;54.57,-10.26,;58.57,-11.04,;59.9,-10.27,;59.9,-8.73,;61.23,-7.96,;61.23,-6.42,;62.56,-5.64,;63.89,-6.41,;65.22,-5.64,;65.22,-4.1,;66.55,-3.32,;67.88,-4.09,;69.21,-3.31,;70.54,-4.07,;70.55,-5.61,;71.89,-6.38,;69.22,-6.39,;67.89,-5.63,;63.87,-3.33,;62.55,-4.11,;62.57,-8.72,;64.03,-8.24,;64.94,-9.49,;64.03,-10.74,;64.51,-12.2,;63.61,-13.45,;64.51,-14.69,;65.98,-14.22,;65.98,-12.68,;62.57,-10.26,;61.23,-11.04,)|
Structure:
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