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Target
Melanocortin receptor 5
Ligand
BDBM50114750
Substrate
n/a
Meas. Tech.
ChEMBL_1844479 (CHEMBL4344906)
EC50
2000±n/a nM
Citation
 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy. ACS Med Chem Lett 11:272-277 (2020) [PubMed]  Article 
Target
Name:
Melanocortin receptor 5
Synonyms:
MC5R_MOUSE | Mc5r | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36966.58
Organism:
Mus musculus (Mouse)
Description:
P41149
Residue:
325
Sequence:
MNSSSTLTVLNLTLNASEDGILGSNVKNKSLACEEMGIAVEVFLTLGLVSLLENILVIGAIVKNKNLHSPMYFFVGSLAVADMLVSMSNAWETVTIYLLNNKHLVIADTFVRHIDNVFDSMICISVVASMCSLLAIAVDRYITIFYALRYHHIMTARRSGVIIACIWTFCISCGIVFIIYYESKYVIICLISMFFTMLFFMVSLYIHMFLLARNHVKRIAASPRYNSVRQRTSMKGAITLTMLLGIFIVCWSPFFLHLILMISCPQNVYCSCFMSYFNMYLILIMCNSVIDPLIYALRSQEMRRTFKEIVCCHGFRRPCRLLGGY
  
Inhibitor
Name:
BDBM50114750
Synonyms:
3-{2-[1-[1-[1-acetyl-(5S)-dihydro-1H-5-pyrrolylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-4-amino(imino)methylamino-(1S)-butylcarboxamido]-2-carbamoylethyl}-1H-indole | CHEMBL320157
Type:
Small organic molecule
Emp. Form.:
C33H43N9O5
Mol. Mass.:
645.7518
SMILES:
CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Structure:
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