Reaction Details
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Platelet factor 4
Ligand
BDBM50511576
Substrate
n/a
Meas. Tech.
ChEMBL_1845082 (CHEMBL4345509)
Kd
16010±n/a nM
Citation
Zhu, S; Li, J; Loka, RS; Song, Z; Vlodavsky, I; Zhang, K; Nguyen, HM Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides. J Med Chem 63:4227-4255 (2020) [PubMed] Article More Info.:
Target
Name:
Platelet factor 4
Synonyms:
C-X-C motif chemokine 4 | CXCL4 | Iroplact | Oncostatin-A | PF-4 | PF4 | PLF4_HUMAN | Platelet factor 4, short form | SCYB4
Type:
PROTEIN
Mol. Mass.:
10849.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108377
Residue:
101
Sequence:
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES
Inhibitor
Name:
BDBM50511576
Synonyms:
CHEMBL4537045
Type:
Small organic molecule
Emp. Form.:
C20H31N3Na6O30S5
Mol. Mass.:
1091.726
SMILES:
[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[H][C@]1([#8]-[#6@H]-2-[#6@H](-[#8])-[#6@@H](-[#8])-[#6@H](-[#8][C@@]3([H])[#6@H](-[#8])-[#6@@H](-[#7]S([#8-])(=O)=O)-[#6@@H](-[#8]-[#6]-[#6]-[#7]S([#8-])(=O)=O)-[#8]-[#6@@H]3-[#6]-[#8]S([#8-])(=O)=O)-[#8]-[#6@@H]-2-[#6](-[#8-])=O)[#8]-[#6@H](-[#6]-[#8]S([#8-])(=O)=O)-[#6@@H](-[#8])-[#6@H](-[#8])-[#6@H]1-[#7]S([#8-])(=O)=O |r|
Structure:
