Reaction Details Report a problem with these data
Target
Histone acetyltransferase KAT2B
Ligand
BDBM50512984
Substrate
n/a
Meas. Tech.
ChEMBL_1850994 (CHEMBL4351618)
Kd
935±n/a nM
Citation
 Huang, L; Li, H; Li, L; Niu, L; Seupel, R; Wu, C; Cheng, W; Chen, C; Ding, B; Brennan, PE; Yang, S Discovery of Pyrrolo[3,2- d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain. J Med Chem 62:4526-4542 (2019) [PubMed]  Article 
Target
Name:
Histone acetyltransferase KAT2B
Synonyms:
Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF
Type:
PROTEIN
Mol. Mass.:
93045.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502838
Residue:
832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
  
Inhibitor
Name:
BDBM50512984
Synonyms:
CHEMBL4547880
Type:
Small organic molecule
Emp. Form.:
C23H29N5O2
Mol. Mass.:
407.5087
SMILES:
[H][C@]12CCC[C@]([H])(C[C@@H](C1)Nc1nc3cc[nH]c3c(=O)n1C)N2C[C@H](O)c1ccccc1 |r,TLB:23:22:3.2.4:8.7.9|
Structure:
Search PDB for entries with ligand similarity: