Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50068526
Substrate
n/a
Meas. Tech.
ChEMBL_2658 (CHEMBL618907)
Ki
130±n/a nM
Citation
 Metwally, KA; Dukat, M; Egan, CT; Smith, C; DuPre, A; Gauthier, CB; Herrick-Davis, K; Teitler, M; Glennon, RA Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding. J Med Chem 41:5084-93 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50068526
Synonyms:
1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-4-methylamino-piperidine-4-carboxylic acid amide | CHEMBL147363
Type:
Small organic molecule
Emp. Form.:
C17H24FN3O2
Mol. Mass.:
321.3898
SMILES:
CNC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)C(N)=O
Structure:
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