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Target
Histone deacetylase 3
Ligand
BDBM197366
Substrate
n/a
Meas. Tech.
ChEMBL_1856766 (CHEMBL4357495)
IC50
28±n/a nM
Citation
 Zhang, SW; Gong, CJ; Su, MB; Chen, F; He, T; Zhang, YM; Shen, QQ; Su, Y; Ding, J; Li, J; Chen, Y; Nan, FJ Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors. J Med Chem 63:804-815 (2020) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM197366
Synonyms:
US9216962, CFH401
Type:
Small organic molecule
Emp. Form.:
C18H16N4O3S2
Mol. Mass.:
400.475
SMILES:
ONC(=O)c1ccc(CNC(=O)c2nc(sc2C2CC2)-c2nccs2)cc1
Structure:
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