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Target
Mu-type opioid receptor
Ligand
BDBM50514540
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
716±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514540
Synonyms:
CHEMBL4439997
Type:
Small organic molecule
Emp. Form.:
C23H34N2O
Mol. Mass.:
354.5289
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CO)c2ccccc12 |r,wD:6.9,3.2,(63.96,-12.85,;63.15,-11.53,;63.89,-10.17,;61.61,-11.57,;60.8,-10.27,;59.26,-10.31,;58.53,-11.66,;59.34,-12.98,;60.88,-12.93,;56.99,-11.72,;56.27,-13.07,;54.73,-13.13,;53.91,-11.82,;54.63,-10.46,;56.18,-10.41,;52.38,-11.88,;51.43,-10.66,;49.98,-11.19,;48.71,-10.33,;48.82,-8.8,;50.04,-12.73,;48.94,-13.79,;49.31,-15.29,;50.79,-15.7,;51.89,-14.63,;51.52,-13.16,)|
Structure:
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