Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 2
Ligand
BDBM50514764
Substrate
n/a
Meas. Tech.
ChEMBL_1858334 (CHEMBL4359063)
EC50
3910±n/a nM
Citation
 Qiu, Y; Huang, L; Fu, J; Han, C; Fang, J; Liao, P; Chen, Z; Mo, Y; Sun, P; Liao, D; Yang, L; Wang, J; Zhang, Q; Liu, J; Liu, F; Liu, T; Huang, W; Yang, H; Jiang, R TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem 63:3665-3677 (2020) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
Protein
Mol. Mass.:
47099.16
Organism:
Homo sapiens (Human)
Description:
O95069
Residue:
426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM50514764
Synonyms:
CHEMBL4552751
Type:
Small organic molecule
Emp. Form.:
C21H20N2O3S
Mol. Mass.:
380.46
SMILES:
Cc1ccc2nc(sc2c1)-c1ccc(NC(=O)[C@@H]2CC[C@@H](C2)C(O)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: