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Target
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Ligand
BDBM50514847
Substrate
n/a
Meas. Tech.
ChEMBL_1858838 (CHEMBL4359567)
Kd
3070±n/a nM
Citation
 Sivaraman, A; Kim, DG; Bhattarai, D; Kim, M; Lee, HY; Lim, S; Kong, J; Goo, JI; Shim, S; Lee, S; Suh, YG; Choi, Y; Kim, S; Lee, K Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem 63:5139-5158 (2020) [PubMed]  Article 
Target
Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Synonyms:
AIMP2 | AIMP2_HUMAN | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | JTV1 | JTV1 | Multisynthase complex auxiliary component p38 | Protein JTV-1
Type:
PROTEIN
Mol. Mass.:
35355.45
Organism:
Homo sapiens
Description:
ChEMBL_119035
Residue:
320
Sequence:
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
  
Inhibitor
Name:
BDBM50514847
Synonyms:
CHEMBL4558745
Type:
Small organic molecule
Emp. Form.:
C28H26N4O4S2
Mol. Mass.:
546.66
SMILES:
COc1ccc(cc1)-c1csc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NS(=O)(=O)c2ccc(C)cc2)n1 |r|
Structure:
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