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Target
Carbonic anhydrase 12
Ligand
BDBM50515304
Substrate
n/a
Meas. Tech.
ChEMBL_1860801 (CHEMBL4361657)
Ki
30±n/a nM
Citation
 Berrino, E; Milazzo, L; Micheli, L; Vullo, D; Angeli, A; Bozdag, M; Nocentini, A; Menicatti, M; Bartolucci, G; di Cesare Mannelli, L; Ghelardini, C; Supuran, CT; Carta, F Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem 62:7233-7249 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50515304
Synonyms:
CHEMBL4519372
Type:
Small organic molecule
Emp. Form.:
C11H8O4S
Mol. Mass.:
236.244
SMILES:
O=S1(=O)Oc2cc(OCC#C)ccc2C=C1 |c:15|
Structure:
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