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Target
Fe(3+)-Zn(2+) purple acid phosphatase
Ligand
BDBM50311531
Substrate
n/a
Meas. Tech.
ChEMBL_1862247 (CHEMBL4363103)
Ki
160000±n/a nM
Citation
 Feder, D; Kan, MW; Hussein, WM; Guddat, LW; Schenk, G; McGeary, RP Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Fe(3+)-Zn(2+) purple acid phosphatase
Synonyms:
Iron(III)-zinc(II) purple acid phosphatase | PAP | PPAF_PHAVU
Type:
PROTEIN
Mol. Mass.:
52875.57
Organism:
Phaseolus vulgaris
Description:
ChEMBL_560427
Residue:
459
Sequence:
MGVVKGLLALALVLNVVVVSNGGKSSNFVRKTNKNRDMPLDSDVFRVPPGYNAPQQVHITQGDLVGRAMIISWVTMDEPGSSAVRYWSEKNGRKRIAKGKMSTYRFFNYSSGFIHHTTIRKLKYNTKYYYEVGLRNTTRRFSFITPPQTGLDVPYTFGLIGDLGQSFDSNTTLSHYELSPKKGQTVLFVGDLSYADRYPNHDNVRWDTWGRFTERSVAYQPWIWTAGNHEIEFAPEINETEPFKPFSYRYHVPYEASQSTSPFWYSIKRASAHIIVLSSYSAYGRGTPQYTWLKKELRKVKRSETPWLIVLMHSPLYNSYNHHFMEGEAMRTKFEAWFVKYKVDVVFAGHVHAYERSERVSNIAYKITNGLCTPVKDQSAPVYITIGDAGNYGVIDSNMIQPQPEYSAFREASFGHGMFDIKNRTHAHFSWNRNQDGVAVEADSVWFFNRHWYPVDDST
  
Inhibitor
Name:
BDBM50311531
Synonyms:
(2-Carboxyethyl)-phosphonic acid | 3-PHOSPHONOPROPANOIC ACID | CHEMBL1088324
Type:
Small organic molecule
Emp. Form.:
C3H7O5P
Mol. Mass.:
154.0584
SMILES:
OC(=O)CCP(O)(O)=O
Structure:
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