Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50071061
Substrate
n/a
Meas. Tech.
ChEBML_90727
IC50
550000±n/a nM
Citation
 Zhang, J; Neamati, N; Pommier, Y; Nair, V Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases. Bioorg Med Chem Lett 8:1887-90 (1999) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50071061
Synonyms:
CHEMBL417929 | Disodium; [5-(8-amino-3H-imidazo[4,5-g]quinazolin-3-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphonium
Type:
Small organic molecule
Emp. Form.:
C14H14N5O5P
Mol. Mass.:
363.2663
SMILES:
Nc1ncnc2cc3n(cnc3cc12)C1CCC(COP([O-])([O-])=O)O1
Structure:
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