Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50518184
Substrate
n/a
Meas. Tech.
ChEMBL_1870667 (CHEMBL4371834)
IC50
2.0±n/a nM
Citation
 Harcken, C; Sarko, C; Mao, C; Lord, J; Raudenbush, B; Razavi, H; Liu, P; Swinamer, A; Disalvo, D; Lee, T; Lin, S; Kukulka, A; Grbic, H; Patel, M; Patel, M; Fletcher, K; Joseph, D; White, D; Amodeo, L; Berg, K; Brown, M; Thomson, DS Discovery and optimization of pyrazole amides as antagonists of CCR1. Bioorg Med Chem Lett 29:435-440 (2019) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50518184
Synonyms:
CHEMBL4444976
Type:
Small organic molecule
Emp. Form.:
C22H22ClN7O2
Mol. Mass.:
451.909
SMILES:
COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1nc(-c2ncc[nH]2)c2cccnc12
Structure:
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