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Target
cGMP-specific 3',5'-cyclic phosphodiesterase
Ligand
BDBM50518221
Substrate
n/a
Meas. Tech.
ChEMBL_1870946 (CHEMBL4372113)
IC50
555±n/a nM
Citation
 Pobsuk, N; Paracha, TU; Chaichamnong, N; Salaloy, N; Suphakun, P; Hannongbua, S; Choowongkomon, K; Pekthong, D; Chootip, K; Ingkaninan, K; Gleeson, MP Design, synthesis and evaluation of N Bioorg Med Chem Lett 29:267-270 (2019) [PubMed]  Article 
Target
Name:
cGMP-specific 3',5'-cyclic phosphodiesterase
Synonyms:
PDE5A_RAT | Pde5 | Pde5a | Phosphodiesterase 5A
Type:
PROTEIN
Mol. Mass.:
94547.60
Organism:
Rattus norvegicus
Description:
ChEMBL_155367
Residue:
833
Sequence:
MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
  
Inhibitor
Name:
BDBM50518221
Synonyms:
CHEMBL4450878
Type:
Small organic molecule
Emp. Form.:
C21H21N5O4S2
Mol. Mass.:
471.553
SMILES:
COc1cc2nc(Nc3cccc(c3)S(N)(=O)=O)nc(NCc3cccs3)c2cc1OC
Structure:
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