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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50519025
Substrate
n/a
Meas. Tech.
ChEMBL_1873795 (CHEMBL4375084)
Ki
18000±n/a nM
Citation
 Szlávik, Z; Ondi, L; Csékei, M; Paczal, A; Szabó, ZB; Radics, G; Murray, J; Davidson, J; Chen, I; Davis, B; Hubbard, RE; Pedder, C; Dokurno, P; Surgenor, A; Smith, J; Robertson, A; LeToumelin-Braizat, G; Cauquil, N; Zarka, M; Demarles, D; Perron-Sierra, F; Claperon, A; Colland, F; Geneste, O; Kotschy, A Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J Med Chem 62:6913-6924 (2019) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50519025
Synonyms:
CHEMBL4476787
Type:
Small organic molecule
Emp. Form.:
C18H18N2O3S
Mol. Mass.:
342.412
SMILES:
CCc1sc2ncnc(O[C@H](C)C(O)=O)c2c1-c1ccccc1C |r,wU:10.10,(15.8,-11.63,;15.03,-10.29,;13.49,-10.29,;12.59,-11.54,;11.13,-11.07,;9.79,-11.85,;8.45,-11.08,;8.45,-9.53,;9.79,-8.76,;9.79,-7.22,;8.44,-6.45,;8.43,-4.91,;7.11,-7.23,;5.77,-6.46,;7.11,-8.77,;11.12,-9.52,;12.59,-9.05,;13.06,-7.58,;12.03,-6.45,;12.5,-4.99,;14.01,-4.66,;15.04,-5.8,;14.58,-7.27,;15.61,-8.41,)|
Structure:
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