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Target
Histamine H1 receptor
Ligand
BDBM50063449
Substrate
n/a
Meas. Tech.
ChEBML_84704
Ki
6.4±n/a nM
Citation
 Piwinski, JJ; Wong, JK; Green, MJ; Kaminski, JJ; Colizzo, F; Albanese, MM; Ganguly, AK; Billah, MM; Anthes, JC; West, RE Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. Bioorg Med Chem Lett 8:3469-74 (1999) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM50063449
Synonyms:
8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | CHEMBL117406
Type:
Small organic molecule
Emp. Form.:
C18H20ClN3
Mol. Mass.:
313.825
SMILES:
Clc1ccc2C(N3CCNCC3)c3ncccc3CCc2c1
Structure:
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