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Target
Purine nucleoside phosphorylase
Ligand
BDBM50293091
Substrate
n/a
Meas. Tech.
ChEMBL_1875754 (CHEMBL4377148)
Kd
55±n/a nM
Citation
 Cheviet, T; Lefebvre-Tournier, I; Wein, S; Peyrottes, S Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues. J Med Chem 62:8365-8391 (2019) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50293091
Synonyms:
7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE | 7-({[(2R,3S)-1,3,4-Trihydroxybutan-2-yl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL475537
Type:
Small organic molecule
Emp. Form.:
C11H16N4O4
Mol. Mass.:
268.2691
SMILES:
OC[C@@H](O)[C@@H](CO)NCc1c[nH]c2c1nc[nH]c2=O |r|
Structure:
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