Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50519809
Substrate
n/a
Meas. Tech.
ChEMBL_1878474 (CHEMBL4379868)
Ki
144±n/a nM
Citation
 Bua, S; Lomelino, C; Murray, AB; Osman, SM; ALOthman, ZA; Bozdag, M; Abdel-Aziz, HA; Eldehna, WM; McKenna, R; Nocentini, A; Supuran, CT "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J Med Chem 63:321-333 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50519809
Synonyms:
CHEMBL4437873
Type:
Small organic molecule
Emp. Form.:
C8H8N2O3S
Mol. Mass.:
212.226
SMILES:
Cc1cccc2c1NC(=O)NS2(=O)=O
Structure:
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