Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50520044
Substrate
n/a
Meas. Tech.
ChEMBL_1878952 (CHEMBL4380346)
Ki
550±n/a nM
Citation
 Ballante, F; Rudling, A; Zeifman, A; Luttens, A; Vo, DD; Irwin, JJ; Kihlberg, J; Brea, J; Loza, MI; Carlsson, J Docking Finds GPCR Ligands in Dark Chemical Matter. J Med Chem 63:613-620 (2020) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50520044
Synonyms:
CHEMBL1406529
Type:
Small organic molecule
Emp. Form.:
C18H17ClN2
Mol. Mass.:
296.794
SMILES:
Cc1cccc2cc(CNCc3ccccc3)c(Cl)nc12
Structure:
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