Reaction Details Report a problem with these data
Target
Pro-cathepsin H
Ligand
BDBM50074048
Substrate
n/a
Meas. Tech.
ChEMBL_45535 (CHEMBL661055)
Ki
210000±n/a nM
Citation
 Schirmeister, T New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid. J Med Chem 42:560-72 (1999) [PubMed]  Article 
Target
Name:
Pro-cathepsin H
Synonyms:
CATH_HUMAN | CBSP | CPSB | CTSH | Cathepsin H | Cathepsin H heavy chain | Cathepsin H light chain | Cathepsin H mini chain
Type:
PROTEIN
Mol. Mass.:
37402.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459870
Residue:
335
Sequence:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
  
Inhibitor
Name:
BDBM50074048
Synonyms:
1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-aziridine-2,3-dicarboxylic acid diethyl ester | CHEMBL2371121
Type:
Small organic molecule
Emp. Form.:
C22H30N2O7
Mol. Mass.:
434.4828
SMILES:
CCOC(=O)[C@@H]1[C@H](N1C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)OCC
Structure:
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