Reaction Details Report a problem with these data
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50074939
Substrate
n/a
Meas. Tech.
ChEBML_212262
IC50
3000±n/a nM
Citation
 Chen, MH; Steiner, MG; de Laszlo, SE; Patchett, AA; Anderson, MS; Hyland, SA; Onishi, HR; Silver, LL; Raetz, CR Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis. Bioorg Med Chem Lett 9:313-8 (1999) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33952.00
Organism:
Escherichia coli
Description:
P0A725
Residue:
305
Sequence:
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
  
Inhibitor
Name:
BDBM50074939
Synonyms:
2-Phenyl-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide | CHEMBL108805 | L-573655
Type:
Small organic molecule
Emp. Form.:
C10H10N2O3
Mol. Mass.:
206.198
SMILES:
ONC(=O)C1COC(=N1)c1ccccc1 |c:7|
Structure:
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