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Target
Polypeptide N-acetylgalactosaminyltransferase 2
Ligand
BDBM50085536
Substrate
n/a
Meas. Tech.
ChEMBL_1885030 (CHEMBL4386612)
Kd
924±n/a nM
Citation
 Liu, F; Cui, Y; Yang, F; Xu, Z; Da, LT; Zhang, Y Inhibition of polypeptide N-acetyl-?-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis. Bioorg Med Chem 27:3372-3382 (2019) [PubMed]  Article 
Target
Name:
Polypeptide N-acetylgalactosaminyltransferase 2
Synonyms:
GALNT2 | GALT2_HUMAN | GalNAc-T2 | Polypeptide GalNAc transferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 | Polypeptide N-acetylgalactosaminyltransferase 2 soluble form | Protein-UDP acetylgalactosaminyltransferase 2 | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2 | pp-GaNTase 2
Type:
PROTEIN
Mol. Mass.:
64746.16
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115316
Residue:
571
Sequence:
MRRRSRMLLCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQQ
  
Inhibitor
Name:
BDBM50085536
Synonyms:
3,4,5-Trihydroxybenzoate, X | 3,4,5-trihydroxybenzoic acid | CHEMBL288114 | Gallic Acid, F | gallic acid
Type:
Small organic molecule
Emp. Form.:
C7H6O5
Mol. Mass.:
170.1195
SMILES:
OC(=O)c1cc(O)c(O)c(O)c1
Structure:
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