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Target
Cholinesterase
Ligand
BDBM50076632
Substrate
n/a
Meas. Tech.
ChEBML_41583
IC50
350±n/a nM
Citation
 Degen, SJ; Mueller, KL; Shen, HC; Mulder, JA; Golding, GM; Wei, LL; Zificsak, CA; Neeno-Eckwall, A; Hsung, RP Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorg Med Chem Lett 9:973-8 (1999) [PubMed]  Article 
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
  
Inhibitor
Name:
BDBM50076632
Synonyms:
(8aS,10aS)-6-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-9-oxo-5,10a-dihydro-8H,9H-xanthene-8a-carbonitrile | CHEMBL360907
Type:
Small organic molecule
Emp. Form.:
C21H27NO4Si
Mol. Mass.:
385.5289
SMILES:
COC1C=C(C[C@@H]2Oc3ccccc3C(=O)[C@]12C#N)O[Si](C)(C)C(C)(C)C |c:3|
Structure:
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