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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50521755
Substrate
n/a
Meas. Tech.
ChEMBL_1885222 (CHEMBL4386804)
EC50
17±n/a nM
Citation
 Chopko, TC; Han, C; Gregro, AR; Engers, DW; Felts, AS; Poslusney, MS; Bollinger, KA; Morrison, RD; Bubser, M; Lamsal, A; Luscombe, VB; Cho, HP; Schnetz-Boutaud, NC; Rodriguez, AL; Chang, S; Daniels, JS; Stec, DF; Niswender, CM; Jones, CK; Wood, MR; Wood, MW; Duggan, ME; Brandon, NJ; Conn, PJ; Bridges, TM; Lindsley, CW; Melancon, BJ SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M Bioorg Med Chem Lett 29:2224-2228 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50521755
Synonyms:
CHEMBL4575270
Type:
Small organic molecule
Emp. Form.:
C19H17N5OS
Mol. Mass.:
363.436
SMILES:
Cc1cc2nncn2c2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12
Structure:
Search PDB for entries with ligand similarity: