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Target
Polyphenol oxidase 2
Ligand
BDBM50521808
Substrate
n/a
Meas. Tech.
ChEMBL_1885372 (CHEMBL4386954)
IC50
63100±n/a nM
Citation
 Santi, MD; Peralta, MA; Puiatti, M; Cabrera, JL; Ortega, MG Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies. Bioorg Med Chem 27:3722-3728 (2019) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50521808
Synonyms:
CHEMBL4462424
Type:
Small organic molecule
Emp. Form.:
C17H16O4
Mol. Mass.:
284.3065
SMILES:
COc1cc(O)c(C(=O)\C=C\c2ccccc2)c(O)c1C
Structure:
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