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Target
Serine protease 1
Ligand
BDBM50076908
Substrate
n/a
Meas. Tech.
ChEBML_212726
Ki
200±n/a nM
Citation
 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa. Bioorg Med Chem Lett 9:1195-200 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50076908
Synonyms:
(3R,4S)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid methyl ester with 2M of TFA | CHEMBL277994
Type:
Small organic molecule
Emp. Form.:
C26H28N4O4S
Mol. Mass.:
492.59
SMILES:
COC(=O)[C@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@@H]1c1cccc(c1)C(N)=N
Structure:
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