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Target
Kallikrein-8
Ligand
BDBM50522493
Substrate
n/a
Meas. Tech.
ChEMBL_1886797 (CHEMBL4388474)
IC50
794±n/a nM
Citation
 Walker, AL; Bingham, RP; Edgar, EV; Ferrie, A; Holmes, DS; Liddle, J; Polyakova, O; Rella, M; Smith, KJ; Thorpe, JH; Wang, Y; White, GV; Young, RJ; Hovnanian, A Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome. Bioorg Med Chem Lett 29:1454-1458 (2019) [PubMed]  Article 
Target
Name:
Kallikrein-8
Synonyms:
KLK8 | KLK8_HUMAN | Kallikrein 8 | Kallikrein-8 | NP | NRPN | Neuropsin | Ovasin | PRSS19 | Serine protease 19 | Serine protease TADG-14 | TADG14 | Tumor-associated differentially expressed gene 14 protein | hK8
Type:
PROTEIN
Mol. Mass.:
28053.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_600069
Residue:
260
Sequence:
MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG
  
Inhibitor
Name:
BDBM50522493
Synonyms:
CHEMBL4530083
Type:
Small organic molecule
Emp. Form.:
C23H22N6O
Mol. Mass.:
398.4604
SMILES:
NC(=N)c1ccc(NCc2nc(c[nH]2)-c2ccccc2)cc1OCc1cccnc1
Structure:
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