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Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM50522535
Substrate
n/a
Meas. Tech.
ChEMBL_1886964 (CHEMBL4388641)
IC50
>63000±n/a nM
Citation
 Washburn, A; Abdeen, S; Ovechkina, Y; Ray, AM; Stevens, M; Chitre, S; Sivinski, J; Park, Y; Johnson, J; Hoang, QQ; Chapman, E; Parish, T; Johnson, SM Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections. Bioorg Med Chem Lett 29:1665-1672 (2019) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial
Type:
Oxidoreductase; homodimer
Mol. Mass.:
35493.48
Organism:
Sus scrofa (pig)
Description:
Porcine heart mitochondria.
Residue:
337
Sequence:
MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFVAELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEKNLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
  
Inhibitor
Name:
BDBM50522535
Synonyms:
CHEMBL4458229
Type:
Small organic molecule
Emp. Form.:
C19H14N2O4S
Mol. Mass.:
366.39
SMILES:
Oc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1nc2ccccc2o1
Structure:
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