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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50522850
Substrate
n/a
Meas. Tech.
ChEMBL_1888586 (CHEMBL4390263)
IC50
22200±n/a nM
Citation
 Salem, MG; Aziz, YMA; Elewa, M; Elshihawy, HA; Said, MM Synthesis and molecular modeling of novel non-sulfonylureas as hypoglycemic agents and selective ALR2 inhibitors. Bioorg Med Chem 27:3383-3389 (2019) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50522850
Synonyms:
CHEMBL4447267
Type:
Small organic molecule
Emp. Form.:
C23H16ClN3O3
Mol. Mass.:
417.844
SMILES:
Clc1ccc(NC(=O)CN2C(=O)NC3(C2=O)c2ccccc2-c2ccccc32)cc1
Structure:
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