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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50522980
Substrate
n/a
Meas. Tech.
ChEMBL_1888746 (CHEMBL4390423)
Ki
166±n/a nM
Citation
 Zar?ba, P; Ja?kowska, J; Czekaj, I; Sata?a, G Design, synthesis and molecular modelling of new bulky Fananserin derivatives with altered pharmacological profile as potential antidepressants. Bioorg Med Chem 27:3396-3407 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50522980
Synonyms:
CHEMBL4592962
Type:
Small organic molecule
Emp. Form.:
C27H30Cl3N3O
Mol. Mass.:
518.906
SMILES:
Cl.Clc1ccc(cc1Cl)N1CCN(CCCCCCN2C(=O)c3cccc4cccc2c34)CC1
Structure:
Search PDB for entries with ligand similarity: