Reaction Details Report a problem with these data
Target
Plasmepsin IV [1-448]
Ligand
BDBM50523408
Substrate
n/a
Meas. Tech.
ChEMBL_1890278 (CHEMBL4392032)
IC50
>10000±n/a nM
Citation
 Meyers, MJ; Liu, J; Xu, J; Leng, F; Guan, J; Liu, Z; McNitt, SA; Qin, L; Dai, L; Ma, H; Adah, D; Zhao, S; Li, X; Polino, AJ; Nasamu, AS; Goldberg, DE; Liu, X; Lu, Y; Tu, Z; Chen, X; Tortorella, MD 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. J Med Chem 62:3503-3512 (2019) [PubMed]  Article 
Target
Name:
Plasmepsin IV [1-448]
Synonyms:
PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV)
Type:
Enzyme
Mol. Mass.:
50925.00
Organism:
Plasmodium falciparum
Description:
Q8IM16[1-448]
Residue:
448
Sequence:
MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGNFYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYLGSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFILGDPFMRKYFTVFDYEKESVGFAVAKN
  
Inhibitor
Name:
BDBM50523408
Synonyms:
CHEMBL4435264
Type:
Small organic molecule
Emp. Form.:
C21H24F3N3O
Mol. Mass.:
391.43
SMILES:
CN(C)c1ccc(CNC(=O)[C@H]2CNC[C@@H]2c2ccc(cc2)C(F)(F)F)cc1 |r|
Structure:
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