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Target
Plasmepsin II
Ligand
BDBM50523411
Substrate
n/a
Meas. Tech.
ChEMBL_1890277 (CHEMBL4392031)
IC50
>10000±n/a nM
Citation
 Meyers, MJ; Liu, J; Xu, J; Leng, F; Guan, J; Liu, Z; McNitt, SA; Qin, L; Dai, L; Ma, H; Adah, D; Zhao, S; Li, X; Polino, AJ; Nasamu, AS; Goldberg, DE; Liu, X; Lu, Y; Tu, Z; Chen, X; Tortorella, MD 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. J Med Chem 62:3503-3512 (2019) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50523411
Synonyms:
CHEMBL4475207
Type:
Small organic molecule
Emp. Form.:
C20H23F3N4O
Mol. Mass.:
392.418
SMILES:
CN(C)c1ccc(CNC(=O)[C@H]2CNC[C@@H]2c2ccc(nc2)C(F)(F)F)cc1 |r|
Structure:
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