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Target
Xaa-Pro aminopeptidase 2
Ligand
BDBM50078400
Substrate
n/a
Meas. Tech.
ChEMBL_35521 (CHEMBL644754)
IC50
1700000±n/a nM
Citation
 Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem 42:2394-402 (1999) [PubMed]  Article 
Target
Name:
Xaa-Pro aminopeptidase 2
Synonyms:
XPP2_RAT | Xpnpep2
Type:
PROTEIN
Mol. Mass.:
76070.70
Organism:
Rattus norvegicus
Description:
ChEMBL_35521
Residue:
674
Sequence:
MAQAYWQCYPWLVLLCACAWSYPGPESLGREDVRDCSTNPPRLPVTAVNTTMRLAALRQQMEKSNLSAYIIPDTDAHMSEYIGKHDERRAWISGFTGSAGTAVVTKKKAAVWTDSRYWTQAERQMDCNWELHKEVSISSIVAWILAEVPDGENVGFDPFLFSVGSWENYDQELQDSNRHLLSITTNLVDVAWGSERPPVPSQPIYALPKEFTGSTWQEKVSAIRSYMQNHTMAPTGVLLSALDETAWLFNLRSSDIPYNPFFYSYTLLTDSSIRLFVNKSRFSLETLQYLNTNCTLPMCVQLEDYSQIRDGVKAYASGNVKILIGISYTTYGVYDVIPKEKLVTETYSPVMLIKAVKNSKEQALLKASHVRDAVAVIQYLVWLEKNVPKGTVDEFSGAEHIDQLRRNENFSSGPSFETISASGLNAALAHYSPTKELHRKLSLDEMYLVDSGGQYWDGTTDITRTVHWGTPTAFQKEAYTRVLMGNIDLSRLVFPAATSGRVVEAFARRALWEVGLNYGHGTGHGIGNFLCVHEWPVGFQYNNMAMAKGMFTSIEPGYYQDGEFGIRLEDVALVVEAKTKYPGTYLTFELVSFVPYDRNLIDVSLLSPEQLQYLNRYYQTIRENIGPELQRRQLLEEFAWLERHTEPLSASAPHTTSLASMWVASALAILSWSC
  
Inhibitor
Name:
BDBM50078400
Synonyms:
1-[1-(3-Amino-2-hydroxy-4-phenyl-butyryl)-4-hydroxy-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-ethyl)-amide | CHEMBL310868
Type:
Small organic molecule
Emp. Form.:
C23H33N5O6
Mol. Mass.:
475.538
SMILES:
C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CC(O)CN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(N)=O
Structure:
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