Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50525040
Substrate
n/a
Meas. Tech.
ChEMBL_1895321 (CHEMBL4397356)
Ki
33±n/a nM
Citation
 Reilly, SW; Riad, AA; Hsieh, CJ; Sahlholm, K; Jacome, DA; Griffin, S; Taylor, M; Weng, CC; Xu, K; Kirschner, N; Luedtke, RR; Parry, C; Malhotra, S; Karanicolas, J; Mach, RH Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D J Med Chem 62:5132-5147 (2019) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50525040
Synonyms:
CHEMBL4471201
Type:
Small organic molecule
Emp. Form.:
C29H38FN5OS
Mol. Mass.:
523.708
SMILES:
Cn1c(SCCCN2CCC3(CC2)CCN(CC3)c2ccccc2OCCF)nnc1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: