Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50525075
Substrate
n/a
Meas. Tech.
ChEMBL_1895465 (CHEMBL4397500)
EC50
0.450000±n/a nM
Citation
 Wi?niewski, K; Qi, S; Kraus, J; Ly, B; Srinivasan, K; Tariga, H; Croston, G; La, E; Wi?niewska, H; Ortiz, C; Laporte, R; Rivière, PJ; Neyer, G; Hargrove, DM; Schteingart, CD Discovery of Potent, Selective, and Short-Acting Peptidic V J Med Chem 62:4991-5005 (2019) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50525075
Synonyms:
CHEMBL4436571
Type:
Small organic molecule
Emp. Form.:
C46H67ClN12O9S2
Mol. Mass.:
1031.682
SMILES:
CC(C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1 |r|
Structure:
Search PDB for entries with ligand similarity: