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Target
DCN1-like protein 1
Ligand
BDBM50525313
Substrate
n/a
Meas. Tech.
ChEMBL_1896548 (CHEMBL4398583)
Ki
14±n/a nM
Citation
 Zhou, W; Ma, L; Ding, L; Guo, Q; He, Z; Yang, J; Qiao, H; Li, L; Yang, J; Yu, S; Zhao, L; Wang, S; Liu, HM; Suo, Z; Zhao, W Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction. J Med Chem 62:5382-5403 (2019) [PubMed]  Article 
Target
Name:
DCN1-like protein 1
Synonyms:
DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1
Type:
PROTEIN
Mol. Mass.:
30118.96
Organism:
Homo sapiens
Description:
ChEMBL_117443
Residue:
259
Sequence:
MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
  
Inhibitor
Name:
BDBM50525313
Synonyms:
CHEMBL4592844
Type:
Small organic molecule
Emp. Form.:
C18H12N4S3
Mol. Mass.:
380.51
SMILES:
Cc1ccc(cc1)-c1nc(SCC#C)nc(Sc2nccs2)c1C#N
Structure:
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