Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 3
Ligand
BDBM50525532
Substrate
n/a
Meas. Tech.
ChEMBL_1897372 (CHEMBL4399407)
EC50
980±n/a nM
Citation
 Liang, D; Li, L; Lynch, C; Diethelm-Varela, B; Xia, M; Xue, F; Wang, H DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor. ACS Med Chem Lett 10:1039-1044 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 3
Synonyms:
CAR | NR1I3 | NR1I3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39953.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1434936
Residue:
352
Sequence:
MASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEICS
  
Inhibitor
Name:
BDBM50525532
Synonyms:
CHEMBL4580898
Type:
Small organic molecule
Emp. Form.:
C25H19N3O2
Mol. Mass.:
393.4373
SMILES:
C1C(Cc2ccccc12)O\N=C\c1c(nc2occn12)-c1ccc2ccccc2c1
Structure:
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