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Target
Deoxyhypusine hydroxylase
Ligand
BDBM50042874
Substrate
n/a
Meas. Tech.
ChEMBL_1898739 (CHEMBL4400854)
IC50
5000±n/a nM
Citation
 Jiang, Z; You, Q; Zhang, X Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. Eur J Med Chem 165:172-197 (2019) [PubMed]  Article 
Target
Name:
Deoxyhypusine hydroxylase
Synonyms:
1.14.99.29 | DOHH | DOHH_HUMAN | Deoxyhypusine dioxygenase | Deoxyhypusine hydroxylase | Deoxyhypusine monooxygenase | HEAT-like repeat-containing protein 1 | HLRC1 | Synonyms=HLRC1 | hDOHH
Type:
PROTEIN
Mol. Mass.:
32886.24
Organism:
Homo sapiens
Description:
ChEMBL_119191
Residue:
302
Sequence:
MVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETGRAFQYADGLEQLRGAPS
  
Inhibitor
Name:
BDBM50042874
Synonyms:
2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl | 2,2'-dipyridine | 2,2'-dipyridyl | 2-(2-pyridyl)pyridine | CHEMBL39879 | US10196346, Bipyridine | alpha,alpha'-bipyridine | alpha,alpha'-bipyridyl | alpha,alpha'-dipyridine | alpha,alpha'-dipyridyl | bpy
Type:
Small organic molecule
Emp. Form.:
C10H8N2
Mol. Mass.:
156.1839
SMILES:
c1ccc(nc1)-c1ccccn1
Structure:
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