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Target
Dipeptidase 1
Ligand
BDBM50042565
Substrate
n/a
Meas. Tech.
ChEBML_53274
Ki
500000±n/a nM
Citation
 Toney, JH; Cleary, KA; Hammond, GG; Yuan, X; May, WJ; Hutchins, SM; Ashton, WT; Vanderwall, DE Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors. Bioorg Med Chem Lett 9:2741-6 (1999) [PubMed]  Article 
Target
Name:
Dipeptidase 1
Synonyms:
DPEP1 | DPEP1_PIG | Dipeptidase 1 | Leukotriene D4 Alpha | Microsomal dipeptidase | RDP | Renal dipeptidase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44697.32
Organism:
GUINEA PIG
Description:
Leukotriene D4 Alpha 0 GUINEA PIG::P22412
Residue:
409
Sequence:
MWTSWWLWPLVAVCAADQFRDLAVRIMQDTPVIDGHNDLPWQLLNLFNNQLQDPGANLSSLAHTHTNIPKLKAGFVGGQFWSAYVPCDTQNRDAVKRTLEQIDVIQRMCQAYPETFACVTSSTGIRQAFREGKVASLVGVEGGHSIDSSLGVLRALYHLGMRYMTLTHSCNTPWADNWLVDTGDDKAQSQGLSHFGQSVVKEMNRLGVMIDLAHVSVATMRAALKLSQAPVIFSHSSAYSLCPHRRNVPDDVLQLVKETGSLVMVNFYNDYVSCSAKANLSQVADHLDHIKKVAGAAAVGFGGDYDGVSRVPSGLEDVSKYPDLVAELLRRQWTEAEVRGALADNLLRVFEAVEQASNHAQVPGEEPIPLGQLEASCRTNYGYSAAPSLHLPPGSLLASLVPLLLLSLP
  
Inhibitor
Name:
BDBM50042565
Synonyms:
5-Butyl-2-(2,6-dichloro-phenyl)-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid | CHEMBL329616
Type:
Small organic molecule
Emp. Form.:
C28H24Cl2N6O2
Mol. Mass.:
547.435
SMILES:
CCCCc1nn(c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cccc1Cl |(-6.39,-5.83,;-4.86,-5.84,;-4.08,-4.52,;-2.54,-4.53,;-1.61,-3.29,;-2.1,-1.82,;-.85,-.9,;.39,-1.82,;1.86,-1.35,;2.18,.16,;3.35,-2.08,;-.08,-3.29,;.81,-4.53,;2.36,-4.52,;3.12,-5.86,;4.66,-5.84,;5.42,-4.52,;4.63,-3.2,;3.1,-3.2,;6.96,-4.5,;7.72,-5.84,;9.27,-5.84,;10.01,-4.5,;9.25,-3.16,;7.71,-3.16,;7.18,-1.7,;8.42,-.81,;7.94,.66,;6.41,.66,;5.94,-.81,;-1.26,.59,;-2.73,.98,;-3.86,-.07,;-3.12,2.44,;-2.04,3.56,;-.56,3.14,;-.16,1.68,;1.25,1.9,)|
Structure:
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