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Target
Purine nucleoside phosphorylase
Ligand
BDBM50081806
Substrate
n/a
Meas. Tech.
ChEBML_162186
IC50
320±n/a nM
Citation
 Yokomatsu, T; Hayakawa, Y; Suemune, K; Kihara, T; Soeda, S; Shimeno, H; Shibuya, S Synthesis and biological evaluation of 1,1-difluoro-2-(tetrahydro-3-furanyl)ethylphosphonic acids possessing a N9-purinylmethyl functional group at the ring. a new class of inhibitors for purine nucleoside phosphorylases. Bioorg Med Chem Lett 9:2833-6 (1999) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50081806
Synonyms:
CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,6-dihydro-purin-9-ylmethyl)-tetrahydro-furan-3-yl]-ethyl}-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C12H15F2N4O5P
Mol. Mass.:
364.2419
SMILES:
OP(O)(=O)C(F)(F)C[C@H]1COC[C@@H]1Cn1cnc2c1nc[nH]c2=O
Structure:
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