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Target
Heme oxygenase 1
Ligand
BDBM50526840
Substrate
n/a
Meas. Tech.
ChEMBL_1901236 (CHEMBL4403458)
IC50
400±n/a nM
Citation
 Intagliata, S; Salerno, L; Ciaffaglione, V; Leonardi, C; Fallica, AN; Carota, G; Amata, E; Marrazzo, A; Pittalą, V; Romeo, G Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50526840
Synonyms:
CHEMBL4514212
Type:
Small organic molecule
Emp. Form.:
C20H26N4
Mol. Mass.:
322.4472
SMILES:
C(CCn1ccnc1)Cc1ccc(CCCCn2ccnc2)cc1
Structure:
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