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Target
DNA repair protein RAD51 homolog 1
Ligand
BDBM50527107
Substrate
n/a
Meas. Tech.
ChEMBL_1902251 (CHEMBL4404473)
Kd
11000±n/a nM
Citation
 Bagnolini, G; Milano, D; Manerba, M; Schipani, F; Ortega, JA; Gioia, D; Falchi, F; Balboni, A; Farabegoli, F; De Franco, F; Robertson, J; Pellicciari, R; Pallavicini, I; Peri, S; Minucci, S; Girotto, S; Di Stefano, G; Roberti, M; Cavalli, A Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib. J Med Chem 63:2588-2619 (2020) [PubMed]  Article 
Target
Name:
DNA repair protein RAD51 homolog 1
Synonyms:
RAD51 | RAD51A | RAD51_HUMAN | RECA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36960.74
Organism:
Homo sapiens (Human)
Description:
gi_49168602
Residue:
339
Sequence:
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
  
Inhibitor
Name:
BDBM50527107
Synonyms:
CHEMBL4450955
Type:
Small organic molecule
Emp. Form.:
C28H24ClN3O3
Mol. Mass.:
485.961
SMILES:
CCC(=O)N1N=C(CC1c1ccc(OC)cc1)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:5|
Structure:
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