Reaction Details Report a problem with these data
Target
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Ligand
BDBM50527600
Substrate
n/a
Meas. Tech.
ChEMBL_1902887 (CHEMBL4405109)
IC50
3580±n/a nM
Citation
 Lee, S; Kim, DG; Kim, K; Kim, T; Lim, S; Kong, H; Kim, S; Suh, YG 2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment. J Med Chem 63:3908-3914 (2020) [PubMed]  Article 
Target
Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Synonyms:
AIMP2 | AIMP2_HUMAN | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | JTV1 | JTV1 | Multisynthase complex auxiliary component p38 | Protein JTV-1
Type:
PROTEIN
Mol. Mass.:
35355.45
Organism:
Homo sapiens
Description:
ChEMBL_119035
Residue:
320
Sequence:
MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLTTNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKSVPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLFSLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTVADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK
  
Inhibitor
Name:
BDBM50527600
Synonyms:
CHEMBL4576024
Type:
Small organic molecule
Emp. Form.:
C29H37ClN6O2
Mol. Mass.:
537.096
SMILES:
COC1CCCN(C1)c1cc(nc(Nc2cccc(OCCN3CCN(C)CC3)c2)n1)-c1ccc(Cl)cc1
Structure:
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