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Target
Delta-type opioid receptor
Ligand
BDBM50083168
Substrate
n/a
Meas. Tech.
ChEMBL_146900 (CHEMBL751113)
Ki
1.18±n/a nM
Citation
 Salvadori, S; Guerrini, R; Balboni, G; Bianchi, C; Bryant, SD; Cooper, PS; Lazarus, LH Further studies on the Dmt-Tic pharmacophore: hydrophobic substituents at the C-terminus endow delta antagonists to manifest mu agonism or mu antagonism. J Med Chem 42:5010-9 (2000) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50083168
Synonyms:
(S)-2-[(S)-3-(4-Hydroxy-2,6-dimethyl-phenyl)-2-piperidin-1-yl-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | CHEMBL433550
Type:
Small organic molecule
Emp. Form.:
C26H32N2O4
Mol. Mass.:
436.5433
SMILES:
Cc1cc(O)cc(C)c1C[C@H](N1CCCCC1)C(=O)N1Cc2ccccc2C[C@H]1C(O)=O
Structure:
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