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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50186827
Substrate
n/a
Meas. Tech.
ChEMBL_1908152 (CHEMBL4410510)
IC50
95±n/a nM
Citation
 Helal, MA; Chittiboyina, AG; Avery, MA Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50186827
Synonyms:
2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(4-pyrimidin-5-yl-phenyl)-methyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole | CHEMBL379802
Type:
Small organic molecule
Emp. Form.:
C28H25F4N5
Mol. Mass.:
507.5252
SMILES:
Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCN(CC2CC2)CC1)c1ccc(cc1)-c1cncnc1 |(28.2,-34.8,;27.43,-36.13,;25.9,-36.14,;25.14,-37.46,;23.63,-37.78,;23.47,-39.31,;24.88,-39.94,;25.9,-38.79,;27.43,-38.8,;28.2,-37.47,;29.74,-37.47,;31.28,-37.46,;29.74,-39.01,;29.74,-35.93,;22.14,-40.09,;22.14,-41.63,;20.8,-42.39,;20.8,-43.92,;22.13,-44.7,;22.13,-46.24,;20.79,-47,;19.26,-47,;20.03,-48.34,;23.47,-43.93,;23.47,-42.38,;20.8,-39.32,;19.47,-40.09,;18.13,-39.32,;18.14,-37.77,;19.47,-37,;20.8,-37.77,;16.8,-37.01,;16.81,-35.46,;15.48,-34.69,;14.14,-35.46,;14.15,-37.01,;15.48,-37.78,)|
Structure:
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